EYA3

Across TCGA patient cohorts, EYA3 mutation is significantly associated with the RNA expression of many other genes, with 3,336 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EYA3-associated genes across cancer lineages are TIPINP1, RNA5SP412, and RNU4-21P. Each is linked with EYA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EYA3-to-partner and partner-to-EYA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIPINP1 grouped by EYA3-low versus EYA3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA3→partner) and Y-score (partner→EYA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TIPINP1 →	+0.109	+3.978	<.001	.001	3	2
UCEC	RNA5SP412 →	+0.735	+2.507	<.001	<.001	3	2
UCEC	RNU4-21P →	+0.722	+2.286	<.001	.004	3	2
UCEC	KRTAP20-3 →	+0.094	+4.645	<.001	<.001	3	2
UCEC	ATF4P1 →	+0.053	+2.602	<.001	.001	3	2
UCEC	RNA5SP436 →	+0.348	+3.030	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,336 associations by consensus.

TIPINP1 by EYA3 expression — SKCM

Explore this box plot interactively →