EYA3

Across TCGA pan-cancer cohorts, EYA3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of EYA3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EYA3 RNA is repressed in tumor relative to normal tissue. In most cancer types EYA3 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and BLCA are the cancer types where EYA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EYA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.916	<.001	11	view →
THCA	Male	II,III,IV	−0.713	<.001	10	view →
BLCA	Male	All	+0.929	<.001	9	view →
HNSC	Male	All	+0.556	<.001	9	view →
KICH	Female	All	−1.485	<.001	7	view →
LIHC	Female	II,III,IV	+0.820	<.001	7	view →
COAD	All	II,III,IV	+0.536	<.001	7	view →
STAD	All	II,III,IV	+0.778	.003	6	view →
BRCA	All	II,III,IV	+0.302	<.001	6	view →
CHOL	All	All	+1.742	<.001	5	view →
LUSC	Male	II,III,IV	+0.486	<.001	5	view →
UCEC	All	III,IV	+0.851	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

EYA3–KIRC

Open the KIRC breakdown →