Across TCGA cell cohorts, ERV3-1 mutation is significantly associated with the RNA expression of many other genes, with 147 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERV3-1-associated genes across cancer lineages are SCN10A, AQP12A, and SMIM23. Each is linked with ERV3-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERV3-1-to-partner and partner-to-ERV3-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERV3-1→partner) and Y-score (partner→ERV3-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCN10A →	+0.004	+4.662	<.001	.005	3	2
BLOOD_Leukemia	AQP12A →	+0.079	+3.269	<.001	.007	3	2
LUNG_NSCLC_LUSC	SMIM23 →	+0.020	+4.643	<.001	.008	3	1
CNS	TRIM42 →	+0.004	+4.321	<.001	.009	3	1
CNS	WFDC10A →	+0.126	+4.315	<.001	.006	3	1
CNS	IL27 →	+0.074	+4.315	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

Exploration

ERV3-1 survival (RNA) · tumor vs normal (RNA) · all ERV3-1 data types