Across TCGA pan-cancer cohorts, ERV3-1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ERV3-1 data layer compared with 4 for mutation status.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ERV3-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERV3-1 expression acts as an unfavorable survival marker, although some lineages such as UCS and DLBC show a favorable association.
BLCA, UVM, and UCS are the cancer types where ERV3-1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.