EPB42

Across TCGA cell cohorts, EPB42 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPB42-associated genes across cancer lineages are AIPL1, BPY2, and BPY2B. Each is linked with EPB42 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPB42-to-partner and partner-to-EPB42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AIPL1 grouped by EPB42-low versus EPB42-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB42→partner) and Y-score (partner→EPB42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AIPL1 →	+0.089	+3.554	<.001	.007	3	1
LARGE_INTESTINE	BPY2 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2B →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2C →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	DAZ1 →	+0.723	+3.758	<.001	.007	3	1
LARGE_INTESTINE	SPANXN3 →	+0.112	+3.974	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

AIPL1 by EPB42 expression — LARGE_INTESTINE

Explore this box plot interactively →