EPB42

Across TCGA pan-cancer cohorts, EPB42 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated EPB42 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher EPB42 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EPB42 expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

SCLC, STAD, and LUAD are the cancer types where EPB42 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	II,III,IV	0.055	0.702	<.001	72	view →
STAD	OS	Median	II,III,IV	0.462	0.640	.005	55	view →
LUAD	OS	Tertile	All	0.431	0.294	.002	37	view →
KICH	DFS	Quartile	II,III,IV	0.411	1.000	.010	36	view →
OV	DFS	Median	II,III,IV	0.488	0.584	.010	34	view →
UVM	DFS	Median	III,IV	0.268	0.744	.006	28	view →
BRCA	OS	Quartile	III,IV	0.911	0.756	.009	19	view →
BLCA	OS	Tertile	All	0.529	0.344	.019	15	view →
READ	OS	Tertile	III,IV	0.868	0.543	.002	15	view →
LGG	OS	Quartile	All	0.946	0.840	.002	15	view →
SKCM	DFS	Quartile	All	0.664	0.529	.003	14	view →
GBM	DFS	Median	All	0.321	0.171	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

EPB42–SCLC (OS)

Open the SCLC breakdown →