EPB42

Across TCGA pan-cancer cohorts, EPB42 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of EPB42’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where EPB42 RNA is repressed in tumor relative to normal tissue. In most cancer types EPB42 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

LUSC, BRCA, and LUAD are the cancer types where EPB42 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPB42 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.139	<.001	7	view →
BRCA	All	III,IV	−0.958	<.001	6	view →
LUAD	All	III,IV	−0.122	<.001	4	view →
KICH	All	All	−0.041	.001	4	view →
CHOL	All	All	+0.070	.021	2	view →
UCEC	All	All	−0.058	.005	2	view →
KIRC	Male	All	+0.079	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

EPB42–LUSC

Open the LUSC breakdown →