ELF5

Across TCGA patient cohorts, ELF5 mutation is significantly associated with the RNA expression of many other genes, with 2,246 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ELF5-associated genes across cancer lineages are SRIP1, SAA3P, and ZHX3. Each is linked with ELF5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ELF5-to-partner and partner-to-ELF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRIP1 grouped by ELF5-low versus ELF5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ELF5→partner) and Y-score (partner→ELF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SRIP1 →	+0.064	+2.965	<.001	.008	3	3
SKCM	SAA3P →	+0.393	+1.894	<.001	.007	3	2
SKCM	ZHX3 →	+0.548	+3.350	.005	.005	3	2
SKCM	KCNJ14 →	+0.570	+3.925	<.001	<.001	3	2
SKCM	RRP7BP →	+0.435	+3.334	.006	.005	3	2
UCEC	LONP1 →	+0.635	+3.201	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,246 associations by consensus.

SRIP1 by ELF5 expression — SKCM

Explore this box plot interactively →