ELF5

Across TCGA pan-cancer cohorts, ELF5 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ELF5 data layer compared with 6 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher ELF5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ELF5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

DLBC, LGG, and GBM are the cancer types where ELF5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	III,IV	0.120	0.797	<.001	83	view →
LGG	OS	Median	All	0.729	0.875	<.001	48	view →
GBM	OS	Median	All	0.321	0.494	<.001	45	view →
LUAD	DFS	Quartile	All	0.523	0.161	<.001	40	view →
OV	OS	Quartile	IV	0.680	0.318	.001	24	view →
MESO	DFS	Quartile	III,IV	0.587	0.311	.005	21	view →
STAD	DFS	Quartile	All	0.731	0.419	.006	18	view →
LUSC	DFS	Tertile	II,III,IV	0.891	0.542	.009	15	view →
HNSC	OS	Quartile	All	0.851	0.718	.013	13	view →
ESCA	OS	Tertile	II,III,IV	0.793	0.604	.013	12	view →
THCA	DFS	Quartile	All	0.968	0.645	.010	10	view →
KIRP	OS	Tertile	III,IV	0.902	0.648	.025	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ELF5–DLBC (OS)

Open the DLBC breakdown →