EIF2AK1

Across TCGA cell cohorts, EIF2AK1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EIF2AK1-associated genes across cancer lineages are OPRPN, OR2C1, and TRH. Each is linked with EIF2AK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2AK1-to-partner and partner-to-EIF2AK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by EIF2AK1-low versus EIF2AK1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK1→partner) and Y-score (partner→EIF2AK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPRPN →	+0.060	+5.087	<.001	.004	3	1
LARGE_INTESTINE	OR2C1 →	+0.129	+3.578	<.001	.006	3	1
LARGE_INTESTINE	TRH →	+0.067	+3.830	.006	.003	3	1
LARGE_INTESTINE	ARGFX →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	WSCD2 →	+0.120	+3.923	.001	.001	3	1
BREAST	OR10G4 →	+0.032	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OPRPN by EIF2AK1 expression — URINARY_TRACT

Explore this box plot interactively →