EIF2AK1

Across TCGA pan-cancer cohorts, EIF2AK1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of EIF2AK1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where EIF2AK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EIF2AK1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LUAD, BLCA, and HNSC are the cancer types where EIF2AK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF2AK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+1.515	<.001	11	view →
BLCA	Male	All	+1.344	<.001	11	view →
HNSC	All	IV	+0.945	<.001	11	view →
KIRP	Female	All	+0.671	<.001	11	view →
STAD	Male	III,IV	+1.198	<.001	9	view →
LUSC	Male	II,III,IV	+0.898	<.001	9	view →
LIHC	All	II,III,IV	+0.857	<.001	9	view →
COAD	Male	II,III,IV	+0.737	<.001	9	view →
BRCA	All	III,IV	+1.058	<.001	8	view →
UCEC	All	III,IV	+1.131	<.001	6	view →
THCA	Male	All	−0.212	.003	5	view →
ESCA	All	All	+0.860	.024	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

EIF2AK1–LUAD

Open the LUAD breakdown →