EIF2AK1

Across TCGA pan-cancer cohorts, EIF2AK1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated EIF2AK1 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher EIF2AK1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF2AK1 expression acts as an unfavorable survival marker, although some lineages such as CHOL and READ show a favorable association.

UVM, MESO, and KICH are the cancer types where EIF2AK1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.403	0.761	<.001	71	view →
MESO	DFS	Quartile	All	0.248	0.509	.003	59	view →
KICH	OS	Quartile	All	0.635	1.000	.003	53	view →
BLCA	DFS	Tertile	IV	0.266	0.709	.002	53	view →
ACC	DFS	Tertile	All	0.500	0.822	.002	43	view →
PAAD	DFS	Tertile	All	0.386	0.717	.001	38	view →
HNSC	OS	Tertile	All	0.329	0.616	.008	35	view →
LIHC	DFS	Median	All	0.450	0.631	<.001	35	view →
CESC	DFS	Median	All	0.759	0.883	<.001	34	view →
KIRP	DFS	Median	All	0.805	0.897	.023	32	view →
UCS	DFS	Median	All	0.363	0.663	.001	26	view →
LGG	OS	Quartile	All	0.697	0.852	<.001	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

EIF2AK1–UVM (DFS)

Open the UVM breakdown →