EDC4

Across TCGA cell cohorts, EDC4 mutation is significantly associated with the RNA expression of many other genes, with 204 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EDC4-associated genes across cancer lineages are LRRC3C, FAM149A, and ARL6. Each is linked with EDC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both EDC4-to-partner and partner-to-EDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by EDC4-low versus EDC4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDC4→partner) and Y-score (partner→EDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC3C →	+0.168	+2.263	.008	.003	3	3
BLOOD_Leukemia	FAM149A →	+1.414	+3.309	<.001	.006	3	2
LARGE_INTESTINE	ARL6 →	+0.512	+3.502	.002	.001	3	2
LARGE_INTESTINE	SRR →	+0.870	+3.502	.004	.001	3	2
LARGE_INTESTINE	NUDT6 →	+0.694	+3.234	.005	.004	3	2
LARGE_INTESTINE	ZBED8 →	+0.446	+3.502	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 204 associations by consensus.

LRRC3C by EDC4 expression — LARGE_INTESTINE

Explore this box plot interactively →