EDC4

Across TCGA pan-cancer cohorts, EDC4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of EDC4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where EDC4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EDC4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRP, HNSC, and LIHC are the cancer types where EDC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EDC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	+1.274	<.001	10	view →
HNSC	All	III,IV	+0.712	<.001	9	view →
LIHC	Male	All	+0.741	<.001	7	view →
STAD	Male	II,III,IV	+1.017	.002	6	view →
CHOL	Male	All	+1.998	<.001	5	view →
KIRC	Female	All	+0.480	<.001	5	view →
BLCA	Female	III,IV	+0.514	.024	3	view →
THCA	All	All	−0.291	.018	3	view →
COAD	All	All	+0.276	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

EDC4–KIRP

Open the KIRP breakdown →