EDC4

Across TCGA pan-cancer cohorts, EDC4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated EDC4 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher EDC4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated EDC4 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCEC show a favorable association.

SCLC, ACC, and LUSC are the cancer types where EDC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Tertile	II,III,IV	0.749	0.321	<.001	72	view →
ACC	DFS	Tertile	All	0.472	0.858	<.001	67	view →
LUSC	DFS	Quartile	III,IV	0.146	1.000	<.001	62	view →
UCEC	OS	Tertile	III,IV	0.727	0.414	.018	40	view →
UCS	DFS	Tertile	II,III,IV	0.507	0.189	.016	38	view →
LIHC	DFS	Tertile	All	0.423	0.599	<.001	29	view →
MESO	OS	Median	III,IV	0.295	0.471	.019	25	view →
THCA	DFS	Median	IV	0.751	0.973	.005	24	view →
HNSC	DFS	Quartile	IV	0.758	0.543	.003	16	view →
PAAD	OS	Median	II,III,IV	0.492	0.251	.003	15	view →
READ	OS	Median	All	0.823	0.472	.008	14	view →
GBM	DFS	Median	All	0.385	0.201	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

EDC4–SCLC (DFS)

Open the SCLC breakdown →