EDAR

Across TCGA cell cohorts, EDAR mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EDAR-associated genes across cancer lineages are OR14K1, SLCO1C1, and SLC17A4. Each is linked with EDAR in more than 1 cancer types. Because this analysis shows association rather than direction, both EDAR-to-partner and partner-to-EDAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14K1 grouped by EDAR-low versus EDAR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDAR→partner) and Y-score (partner→EDAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR14K1 →	+0.068	+4.022	<.001	.006	3	2
BLOOD_Leukemia	SLCO1C1 →	+0.096	+4.705	<.001	.003	3	1
BLOOD_Leukemia	SLC17A4 →	+0.092	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CER1 →	+1.039	+4.152	<.001	.009	3	1
BLOOD_Leukemia	LYZL4 →	+0.088	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR4K2 →	+0.031	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OR14K1 by EDAR expression — LARGE_INTESTINE

Explore this box plot interactively →