EDAR

Across TCGA pan-cancer cohorts, EDAR RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of EDAR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where EDAR RNA is repressed in tumor relative to normal tissue. In most cancer types EDAR is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and COAD are the cancer types where EDAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EDAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−1.880	<.001	11	view →
KIRC	All	III,IV	−0.664	<.001	11	view →
COAD	Male	All	+1.812	<.001	10	view →
STAD	All	II,III,IV	+1.131	.006	6	view →
BRCA	Female	All	−0.739	<.001	6	view →
HNSC	Male	II,III,IV	−0.720	.026	5	view →
LUAD	Female	All	−0.472	<.001	3	view →
READ	All	All	+1.931	.035	2	view →
CHOL	All	All	+1.701	.008	2	view →
PAAD	Female	All	+1.520	.023	2	view →
UCEC	All	IV	−0.990	.045	2	view →
PRAD	All	All	−0.811	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

EDAR–KICH

Open the KICH breakdown →