EDAR

Across TCGA pan-cancer cohorts, EDAR RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated EDAR data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EDAR RNA is associated with better overall survival. In most high-consensus cancer types, elevated EDAR expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, COAD, and UVM are the cancer types where EDAR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.710	0.549	<.001	101	view →
COAD	DFS	Median	All	0.362	0.637	<.001	45	view →
UVM	DFS	Tertile	III,IV	0.138	0.745	.002	45	view →
BRCA	DFS	Median	All	0.575	0.468	.001	45	view →
READ	DFS	Quartile	All	0.729	0.946	.001	43	view →
KIRP	DFS	Tertile	All	0.978	0.861	.001	40	view →
THYM	DFS	Tertile	II,III,IV	0.963	0.551	.004	38	view →
UCEC	DFS	Quartile	II,III,IV	0.944	0.774	.004	28	view →
ESCA	OS	Quartile	II,III,IV	0.695	0.391	.002	24	view →
ACC	DFS	Tertile	All	0.845	0.587	.004	23	view →
STAD	DFS	Median	All	0.715	0.595	.005	17	view →
LUAD	DFS	Quartile	III,IV	0.431	0.811	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

EDAR–KIRC (OS)

Open the KIRC breakdown →