ECPAS

Across TCGA patient cohorts, ECPAS mutation is significantly associated with the RNA expression of many other genes, with 6,996 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECPAS-associated genes across cancer lineages are COMMD4P2, NEIL2, and TTTY12. Each is linked with ECPAS in more than 3 cancer types. Because this analysis shows association rather than direction, both ECPAS-to-partner and partner-to-ECPAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COMMD4P2 grouped by ECPAS-low versus ECPAS-high in ACC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECPAS→partner) and Y-score (partner→ECPAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	COMMD4P2 →	+0.101	+4.662	<.001	.005	3	4
UCEC	NEIL2 →	+0.393	+2.436	.001	.001	3	3
CESC	TTTY12 →	+0.044	+4.812	<.001	.006	3	3
COAD	ACBD3-AS1 →	-0.523	-2.767	.009	.003	3	3
COAD	HOXC-AS2 →	+0.356	+2.820	.002	.001	3	3
LUAD	MIR4660 →	+0.495	+3.533	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,996 associations by consensus.

COMMD4P2 by ECPAS expression — ACC

Explore this box plot interactively →