ECPAS

Across TCGA pan-cancer cohorts, ECPAS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ECPAS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ECPAS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ECPAS is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where ECPAS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ECPAS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.419	<.001	10	view →
LIHC	Female	II,III,IV	+0.992	<.001	8	view →
THCA	Male	All	−0.407	<.001	8	view →
LUSC	All	All	+0.278	.001	6	view →
CHOL	All	All	+1.581	<.001	5	view →
STAD	All	II,III,IV	+0.688	.004	5	view →
ESCA	Female	All	+0.826	.030	2	view →
UCEC	All	All	−0.588	.002	2	view →
PRAD	All	All	+0.461	<.001	2	view →
KICH	All	All	−0.385	.034	1	view →
KIRP	Male	All	−0.296	.042	1	view →
LUAD	Male	All	+0.288	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ECPAS–HNSC

Open the HNSC breakdown →