ECPAS

Across TCGA pan-cancer cohorts, ECPAS RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ECPAS data layer compared with 12 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ECPAS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ECPAS expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

ACC, KIRC, and KIRP are the cancer types where ECPAS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.186	0.692	<.001	106	view →
KIRC	DFS	Median	All	0.737	0.527	<.001	90	view →
KIRP	DFS	Median	All	0.784	0.934	.001	55	view →
LGG	OS	Median	All	0.745	0.912	<.001	39	view →
LIHC	DFS	Tertile	All	0.470	0.637	<.001	35	view →
BLCA	DFS	Median	All	0.353	0.611	.001	31	view →
MESO	DFS	Quartile	IV	0.205	0.756	.006	28	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
UVM	DFS	Tertile	III,IV	0.217	0.751	.007	14	view →
READ	OS	Quartile	II,III,IV	0.930	0.278	.011	11	view →
THCA	OS	Quartile	II,III,IV	0.595	0.849	.010	10	view →
SCLC	OS	Tertile	II,III,IV	0.812	0.615	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ECPAS–ACC (DFS)

Open the ACC breakdown →