ECPAS

Across TCGA cell cohorts, ECPAS mutation is significantly associated with the RNA expression of many other genes, with 433 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ECPAS-associated genes across cancer lineages are GPR179, GPR148, and PAIP2B. Each is linked with ECPAS in more than 2 cancer types. Because this analysis shows association rather than direction, both ECPAS-to-partner and partner-to-ECPAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR179 grouped by ECPAS-low versus ECPAS-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECPAS→partner) and Y-score (partner→ECPAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GPR179 →	+0.053	+3.665	.009	.001	3	3
SOFT_TISSUE	GPR148 →	+0.017	+4.977	<.001	.002	3	2
LARGE_INTESTINE	PAIP2B →	+0.675	+3.067	.003	.009	3	2
LARGE_INTESTINE	GCH1 →	+0.555	+2.628	.003	.002	3	2
LARGE_INTESTINE	GID4 →	+0.508	+3.389	.003	.001	3	2
BLOOD_Leukemia	SGCB →	+1.478	+3.614	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 433 associations by consensus.

GPR179 by ECPAS expression — OVARY

Explore this box plot interactively →