DKKL1

Across TCGA patient cohorts, DKKL1 mutation is significantly associated with the RNA expression of many other genes, with 162 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DKKL1-associated genes across cancer lineages are RN7SKP17, RN7SKP113, and RNU6-440P. Each is linked with DKKL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKKL1-to-partner and partner-to-DKKL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP17 grouped by DKKL1-low versus DKKL1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKKL1→partner) and Y-score (partner→DKKL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP17 →	+0.143	+5.026	.002	.002	3	2
BLCA	RN7SKP113 →	+0.143	+7.640	<.001	.009	3	2
BLCA	RNU6-440P →	+0.352	+7.640	<.001	.009	3	2
READ	OR52M1 →	+0.086	+5.257	<.001	.002	3	2
READ	USP9YP5 →	+0.122	+6.276	<.001	<.001	3	2
SKCM	OR11L1 →	+0.277	+5.037	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 162 associations by consensus.

RN7SKP17 by DKKL1 expression — BRCA

Explore this box plot interactively →