DKKL1

Across TCGA pan-cancer cohorts, DKKL1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated DKKL1 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DKKL1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DKKL1 expression acts as an unfavorable survival marker, although some lineages such as UVM and LUAD show a favorable association.

KIRC, UVM, and LGG are the cancer types where DKKL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.523	0.716	<.001	84	view →
UVM	OS	Quartile	II,III,IV	0.869	0.346	<.001	72	view →
LGG	DFS	Median	All	0.642	0.829	<.001	49	view →
COAD	OS	Tertile	All	0.812	0.901	.004	41	view →
LIHC	OS	Quartile	All	0.381	0.721	<.001	36	view →
SCLC	OS	Tertile	IV	0.137	0.548	.004	36	view →
MESO	OS	Tertile	All	0.266	0.493	.009	24	view →
ACC	DFS	Median	All	0.465	0.696	.009	20	view →
CHOL	DFS	Quartile	II,III,IV	0.113	0.779	.024	18	view →
LUAD	DFS	Quartile	II,III,IV	0.498	0.264	.018	17	view →
READ	DFS	Tertile	III,IV	0.599	1.000	.006	15	view →
THYM	DFS	Median	All	0.923	0.806	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

DKKL1–KIRC (OS)

Open the KIRC breakdown →