DKK4

Across TCGA patient cohorts, DKK4 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DKK4-associated genes across cancer lineages are Notch1, Rab11, and Caspase-8. Each is linked with DKK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKK4-to-partner and partner-to-DKK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DKK4-low versus DKK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK4→partner) and Y-score (partner→DKK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.183	+2.817	.013	.036	3	1
UCEC	Rab11 →	-0.188	-3.321	.013	.010	3	1
UCEC	Caspase-8 →	-0.390	-3.295	.003	.009	3	1
UCEC	p62 Lck ligand →	+0.557	+3.321	.001	.010	2	1
UCEC	Rab25 →	-0.552	-3.000	.001	.036	2	1
UCEC	BRCA2 →	-0.166	-2.989	.012	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Notch1 by DKK4 expression — UCEC

Explore this box plot interactively →