DKK4

Across TCGA pan-cancer cohorts, DKK4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DKK4 data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher DKK4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DKK4 expression acts as an unfavorable survival marker, although some lineages such as LUSC and KIRP show a favorable association.

UCS, LUSC, and COAD are the cancer types where DKK4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	III,IV	0.142	0.557	.001	54	view →
LUSC	DFS	Tertile	II,III,IV	0.510	0.291	.001	38	view →
COAD	DFS	Median	II,III,IV	0.399	0.573	<.001	35	view →
LUAD	OS	Median	III,IV	0.568	0.752	.005	34	view →
STAD	OS	Median	All	0.409	0.691	<.001	32	view →
KIRP	DFS	Quartile	III,IV	0.874	0.319	.010	24	view →
SCLC	OS	Quartile	All	0.573	0.251	.007	24	view →
UCEC	OS	Quartile	II,III,IV	0.838	0.597	.009	22	view →
KIRC	DFS	Quartile	All	0.511	0.700	.006	19	view →
HNSC	DFS	Median	IV	0.708	0.571	.005	18	view →
PAAD	OS	Median	III,IV	0.629	1.000	.022	14	view →
TGCT	DFS	Median	All	0.550	0.778	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DKK4–UCS (OS)

Open the UCS breakdown →