DIS3L

Across TCGA cell cohorts, DIS3L mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DIS3L-associated genes across cancer lineages are LRRC72, KRTAP5-4, and FGF3. Each is linked with DIS3L in more than 1 cancer types. Because this analysis shows association rather than direction, both DIS3L-to-partner and partner-to-DIS3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC72 grouped by DIS3L-low versus DIS3L-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3L→partner) and Y-score (partner→DIS3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LRRC72 →	+0.070	+4.285	<.001	.007	3	2
SKIN	KRTAP5-4 →	+0.101	+4.977	<.001	.007	3	1
CNS	FGF3 →	+0.053	+4.981	<.001	.008	3	1
BLOOD_Leukemia	SRY →	+0.029	+4.874	<.001	.002	3	1
BLOOD_Leukemia	SMIM31 →	+0.027	+4.276	<.001	.007	3	1
LARGE_INTESTINE	CDX4 →	+0.007	+3.217	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

LRRC72 by DIS3L expression — STOMACH

Explore this box plot interactively →