DIS3L

Across TCGA pan-cancer cohorts, DIS3L RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DIS3L’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DIS3L RNA is repressed in tumor relative to normal tissue. In most cancer types DIS3L is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, CHOL, and LIHC are the cancer types where DIS3L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DIS3L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.829	<.001	9	view →
CHOL	All	All	+0.988	<.001	5	view →
LIHC	Female	All	+0.541	<.001	5	view →
BRCA	Female	All	−0.195	.003	4	view →
UCEC	All	All	−0.488	.010	2	view →
KIRP	Male	All	−0.392	.011	2	view →
PAAD	Female	All	−0.349	.010	2	view →
COAD	All	All	+0.288	.019	2	view →
LUSC	All	All	+0.243	.012	2	view →
STAD	Male	II,III,IV	+0.676	.037	1	view →
LUAD	Female	II,III,IV	−0.333	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DIS3L–THCA

Open the THCA breakdown →