DIS3L

Across TCGA pan-cancer cohorts, DIS3L RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DIS3L data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DIS3L RNA is associated with better overall survival. In most high-consensus cancer types, elevated DIS3L expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

KIRC, OV, and SKCM are the cancer types where DIS3L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.745	0.550	<.001	102	view →
OV	DFS	Median	III,IV	0.190	0.120	.006	48	view →
SKCM	DFS	Quartile	All	0.682	0.515	<.001	43	view →
KIRP	DFS	Median	IV	0.036	0.528	.001	42	view →
UCEC	DFS	Median	III,IV	0.694	0.439	.010	36	view →
UVM	DFS	Tertile	III,IV	0.201	0.690	.003	35	view →
BRCA	OS	Tertile	III,IV	0.917	0.741	.001	31	view →
MESO	DFS	Quartile	III,IV	0.122	0.671	.010	15	view →
KICH	DFS	Median	II,III,IV	0.657	1.000	.025	10	view →
PRAD	DFS	Tertile	All	0.920	0.845	.024	10	view →
CHOL	DFS	Tertile	III,IV	0.172	0.779	.024	9	view →
READ	DFS	Tertile	III,IV	0.916	0.585	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DIS3L–KIRC (OS)

Open the KIRC breakdown →