DHX8

Across TCGA cell cohorts, DHX8 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DHX8-associated genes across cancer lineages are IFNA14, ZNF804B, and OR2T2. Each is linked with DHX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX8-to-partner and partner-to-DHX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA14 grouped by DHX8-low versus DHX8-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX8→partner) and Y-score (partner→DHX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFNA14 →	+0.028	+5.369	<.001	.004	3	2
BLOOD_Lymphoma	ZNF804B →	+0.013	+4.350	<.001	.005	3	2
LUNG_SCLC	OR2T2 →	+0.023	+5.643	<.001	.002	3	1
SOFT_TISSUE	KLK12 →	+1.031	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR7E24 →	+0.029	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.032	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

IFNA14 by DHX8 expression — SOFT_TISSUE

Explore this box plot interactively →