DHX8

Across TCGA pan-cancer cohorts, DHX8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DHX8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DHX8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DHX8 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRP, and BLCA are the cancer types where DHX8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHX8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.846	<.001	12	view →
KIRP	All	II,III,IV	+0.672	<.001	11	view →
BLCA	Male	III,IV	+0.778	<.001	10	view →
LIHC	Female	II,III,IV	+1.052	<.001	9	view →
COAD	Male	All	+0.475	<.001	9	view →
KICH	Female	All	−1.048	<.001	7	view →
LUSC	Female	All	+0.690	<.001	7	view →
STAD	All	II,III,IV	+0.733	<.001	6	view →
LUAD	Male	All	+0.435	<.001	6	view →
BRCA	All	II,III,IV	+0.243	.001	6	view →
CHOL	Male	All	+2.026	<.001	5	view →
READ	All	III,IV	+0.809	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DHX8–HNSC

Open the HNSC breakdown →