DHRS11

Across TCGA patient cohorts, DHRS11 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS11-associated genes across cancer lineages are RNU6-604P, MIR4756, and H3P40. Each is linked with DHRS11 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS11-to-partner and partner-to-DHRS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-604P grouped by DHRS11-low versus DHRS11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS11→partner) and Y-score (partner→DHRS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-604P →	+0.451	+7.485	<.001	<.001	3	2
UCEC	MIR4756 →	+0.250	+4.437	.001	.005	3	2
BLCA	H3P40 →	+0.354	+4.973	<.001	.009	3	1
BLCA	MIR4440 →	+0.442	+5.899	<.001	.002	3	1
BLCA	KRTAP21-1 →	+0.174	+5.177	.006	.007	3	1
BLCA	RNU6-661P →	+0.585	+6.289	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

RNU6-604P by DHRS11 expression — SKCM

Explore this box plot interactively →