DHRS11

Across TCGA pan-cancer cohorts, DHRS11 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DHRS11’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DHRS11 RNA is repressed in tumor relative to normal tissue. In most cancer types DHRS11 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where DHRS11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHRS11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−2.363	<.001	11	view →
KIRC	Male	II,III,IV	−1.380	<.001	11	view →
LUAD	Female	III,IV	+1.024	<.001	11	view →
HNSC	All	II,III,IV	−0.540	<.001	10	view →
LIHC	Female	All	+0.812	<.001	9	view →
BLCA	Male	III,IV	+1.314	<.001	8	view →
KIRP	All	IV	−1.072	<.001	8	view →
KICH	Male	All	−1.063	<.001	8	view →
LUSC	Female	All	+0.984	<.001	8	view →
THCA	Female	II,III,IV	+0.514	<.001	7	view →
BRCA	Female	All	−0.466	<.001	6	view →
READ	All	All	−1.776	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DHRS11–COAD

Open the COAD breakdown →