DHRS11

Across TCGA pan-cancer cohorts, DHRS11 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated DHRS11 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher DHRS11 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DHRS11 expression acts as an unfavorable survival marker, although some lineages such as READ and LUAD show a favorable association.

UVM, READ, and ACC are the cancer types where DHRS11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.412	0.950	<.001	112	view →
READ	OS	Quartile	III,IV	0.894	0.519	.003	81	view →
ACC	DFS	Median	All	0.230	0.698	<.001	74	view →
LUAD	OS	Tertile	III,IV	0.766	0.507	.002	41	view →
MESO	OS	Tertile	All	0.228	0.827	.001	36	view →
HNSC	OS	Quartile	IV	0.661	0.438	.005	27	view →
LGG	DFS	Tertile	All	0.747	0.892	.003	24	view →
SKCM	OS	Quartile	All	0.305	0.521	.012	21	view →
GBM	OS	Tertile	All	0.213	0.334	.010	12	view →
UCS	DFS	Quartile	III,IV	0.196	0.530	.014	12	view →
LIHC	OS	Tertile	All	0.708	0.810	.012	10	view →
KIRC	DFS	Quartile	IV	0.420	0.696	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

DHRS11–UVM (OS)

Open the UVM breakdown →