DENND4C

Across TCGA cell cohorts, DENND4C mutation is significantly associated with the RNA expression of many other genes, with 1,459 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND4C-associated genes across cancer lineages are PRDM7, OR2AJ1, and CCDC173. Each is linked with DENND4C in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND4C-to-partner and partner-to-DENND4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDM7 grouped by DENND4C-low versus DENND4C-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4C→partner) and Y-score (partner→DENND4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRDM7 →	+0.111	+3.600	<.001	.002	3	2
BLOOD_Lymphoma	OR2AJ1 →	+0.015	+2.867	.001	.009	3	2
LARGE_INTESTINE	CCDC173 →	+0.205	+2.043	<.001	.008	3	2
LARGE_INTESTINE	FBXW10 →	+0.165	+2.215	.002	.003	3	2
LARGE_INTESTINE	TUBB8 →	+0.294	+3.354	<.001	.003	3	2
LARGE_INTESTINE	GAS2L2 →	+0.067	+2.163	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,459 associations by consensus.

PRDM7 by DENND4C expression — BLOOD_Lymphoma

Explore this box plot interactively →