DENND4C

Across TCGA pan-cancer cohorts, DENND4C RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DENND4C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where DENND4C RNA is repressed in tumor relative to normal tissue. In most cancer types DENND4C is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

LUSC, UCEC, and THCA are the cancer types where DENND4C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND4C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−1.518	<.001	8	view →
UCEC	All	All	−1.296	<.001	6	view →
THCA	All	All	−0.495	.002	6	view →
BRCA	Female	All	−0.414	<.001	6	view →
LUAD	Female	All	−0.611	<.001	5	view →
KIRP	Female	II,III,IV	+0.971	.017	4	view →
CHOL	All	All	+0.765	.025	3	view →
COAD	Male	IV	+0.602	.025	1	view →
KICH	All	All	−0.503	.042	1	view →
LIHC	All	All	+0.348	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DENND4C–LUSC

Open the LUSC breakdown →