Across TCGA patient cohorts, DEFB122 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB122-associated genes across cancer lineages are NUDT4P2, ANAPC1P5, and MIR8058. Each is linked with DEFB122 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB122-to-partner and partner-to-DEFB122 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB122→partner) and Y-score (partner→DEFB122) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUDT4P2 →	+0.189	+5.484	<.001	.005	3	1
UCEC	ANAPC1P5 →	+0.263	+5.242	<.001	.007	3	1
UCEC	MIR8058 →	+0.736	+5.081	.002	.008	3	1
UCEC	NUDT4B →	+0.122	+5.621	<.001	.004	3	1
UCEC	AQP7P5 →	+0.095	+5.694	.003	.003	3	1
UCEC	MIR4499 →	+0.664	+5.081	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

DEFB122 survival (RNA) · tumor vs normal (RNA) · all DEFB122 data types