Across TCGA pan-cancer cohorts, DEFB122 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of DEFB122’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where DEFB122 RNA is repressed in tumor relative to normal tissue. In most cancer types DEFB122 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA are the cancer types where DEFB122 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFB122 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	−0.020	.007	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: DEFB122 RNA expression & survival · all DEFB122 data types