DEFA3

Across TCGA patient cohorts, DEFA3 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFA3-associated genes across cancer lineages are RNA5SP290, PTPRJ-AS1, and MTND3P12. Each is linked with DEFA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA3-to-partner and partner-to-DEFA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP290 grouped by DEFA3-low versus DEFA3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA3→partner) and Y-score (partner→DEFA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP290 →	+0.624	+3.679	<.001	.007	3	1
SKCM	PTPRJ-AS1 →	+0.329	+3.612	.003	.008	3	1
SKCM	MTND3P12 →	+0.078	+4.199	<.001	.009	3	1
SKCM	RPL23AP84 →	+0.097	+3.923	<.001	.003	3	1
SKCM	RN7SL178P →	+0.077	+4.624	<.001	.005	3	1
SKCM	RN7SL326P →	+0.117	+4.097	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

RNA5SP290 by DEFA3 expression — SKCM

Explore this box plot interactively →