DEFA3

Across TCGA pan-cancer cohorts, DEFA3 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated DEFA3 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher DEFA3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DEFA3 expression acts as an unfavorable survival marker, although some lineages such as THYM and LIHC show a favorable association.

CHOL, OV, and UCS are the cancer types where DEFA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Tertile	All	0.347	0.832	<.001	57	view →
OV	DFS	Tertile	III,IV	0.294	0.391	.007	54	view →
UCS	DFS	Tertile	IV	0.230	0.767	.009	42	view →
SKCM	OS	Tertile	III,IV	0.485	0.780	.004	33	view →
KIRP	DFS	Tertile	IV	0.040	0.470	.030	30	view →
STAD	DFS	Tertile	IV	0.110	0.595	.012	27	view →
BLCA	OS	Tertile	All	0.189	0.467	.015	27	view →
THYM	OS	Median	All	1.000	0.722	<.001	24	view →
READ	DFS	Tertile	IV	0.027	0.619	<.001	18	view →
UVM	OS	Tertile	All	0.291	0.707	.017	18	view →
LIHC	DFS	Median	III,IV	0.583	0.267	.009	14	view →
ESCA	DFS	Median	III,IV	0.601	0.339	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

DEFA3–CHOL (OS)

Open the CHOL breakdown →