DEFA3

Across TCGA pan-cancer cohorts, DEFA3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of DEFA3’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where DEFA3 RNA is repressed in tumor relative to normal tissue. In most cancer types DEFA3 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and LIHC are the cancer types where DEFA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−1.233	<.001	8	view →
LUAD	All	All	−0.765	<.001	5	view →
LIHC	Male	All	−0.443	<.001	4	view →
BRCA	All	All	−0.045	.027	4	view →
KIRC	Female	All	+0.343	.008	2	view →
PAAD	Male	All	−0.145	.010	2	view →
KICH	Female	All	−0.094	.010	1	view →
THCA	All	II,III,IV	−0.023	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

DEFA3–LUSC

Open the LUSC breakdown →