CYP4B1

Across TCGA cell cohorts, CYP4B1 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CYP4B1-associated genes across cancer lineages are C14orf180, OR2M5, and DUSP21. Each is linked with CYP4B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP4B1-to-partner and partner-to-CYP4B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf180 grouped by CYP4B1-low versus CYP4B1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4B1→partner) and Y-score (partner→CYP4B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C14orf180 →	+0.021	+3.947	<.001	.004	3	3
LARGE_INTESTINE	OR2M5 →	+0.018	+4.000	<.001	<.001	3	2
PANCREAS	DUSP21 →	+0.061	+5.000	<.001	.006	3	1
PANCREAS	SLC5A8 →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	CBLN4 →	+0.006	+5.614	<.001	.002	3	1
BONE	ASCL4 →	+0.016	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

C14orf180 by CYP4B1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →