CYP4B1

Across TCGA pan-cancer cohorts, CYP4B1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CYP4B1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CYP4B1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP4B1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and KIRC are the cancer types where CYP4B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP4B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−3.632	<.001	12	view →
LUAD	Male	III,IV	−6.064	<.001	11	view →
KIRC	Female	All	−1.185	<.001	11	view →
COAD	All	III,IV	−1.332	<.001	10	view →
LUSC	Female	II,III,IV	−6.807	<.001	9	view →
KICH	All	III,IV	−1.538	<.001	9	view →
KIRP	Male	II,III,IV	−1.203	<.001	9	view →
STAD	Male	II,III,IV	−1.592	.009	4	view →
THCA	Male	III,IV	+1.455	<.001	4	view →
PRAD	All	All	−2.067	<.001	2	view →
UCEC	All	All	−1.371	.033	2	view →
READ	All	All	−0.623	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CYP4B1–HNSC

Open the HNSC breakdown →