CYP39A1

Across TCGA patient cohorts, CYP39A1 mutation is significantly associated with the RNA expression of many other genes, with 2,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP39A1-associated genes across cancer lineages are RNA5SP273, RN7SL813P, and CDRT15P7. Each is linked with CYP39A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP39A1-to-partner and partner-to-CYP39A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP273 grouped by CYP39A1-low versus CYP39A1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP39A1→partner) and Y-score (partner→CYP39A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP273 →	+0.518	+6.578	<.001	.001	3	3
CESC	RN7SL813P →	+0.225	+5.103	<.001	.008	3	2
CESC	CDRT15P7 →	+0.078	+5.669	<.001	.003	3	2
COAD	TRBV22OR9-2 →	+0.289	+7.741	<.001	.009	3	2
HNSC	NUDT4B →	+0.101	+4.847	<.001	.002	3	2
HNSC	RNU6-308P →	+0.456	+5.709	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,015 associations by consensus.

RNA5SP273 by CYP39A1 expression — LUSC

Explore this box plot interactively →