CYP39A1

Across TCGA pan-cancer cohorts, CYP39A1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CYP39A1 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CYP39A1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CYP39A1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UVM show a favorable association.

KIRC, LGG, and UVM are the cancer types where CYP39A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.722	0.534	<.001	72	view →
LGG	OS	Tertile	All	0.716	0.901	<.001	45	view →
UVM	DFS	Median	All	0.716	0.437	.003	41	view →
SKCM	DFS	Tertile	All	0.331	0.122	<.001	37	view →
LUAD	DFS	Median	IV	0.272	0.804	.006	32	view →
PRAD	DFS	Median	All	0.959	0.908	.002	18	view →
ACC	DFS	Tertile	All	0.622	0.202	.004	17	view →
DLBC	DFS	Tertile	II,III,IV	1.000	0.625	.012	16	view →
BRCA	DFS	Median	IV	0.349	0.744	.004	14	view →
CHOL	OS	Tertile	II,III,IV	0.365	0.932	.020	13	view →
HNSC	DFS	Median	IV	0.224	0.425	.004	13	view →
LUSC	DFS	Median	All	0.333	0.431	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CYP39A1–KIRC (DFS)

Open the KIRC breakdown →