CYP39A1

Across TCGA pan-cancer cohorts, CYP39A1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CYP39A1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CYP39A1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP39A1 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and LUAD are the cancer types where CYP39A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP39A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−2.022	<.001	11	view →
BLCA	All	IV	−1.677	<.001	11	view →
LUAD	All	III,IV	−1.207	<.001	11	view →
KICH	Male	IV	−2.843	<.001	10	view →
LIHC	Female	II,III,IV	−3.253	<.001	9	view →
LUSC	All	III,IV	−2.110	<.001	9	view →
COAD	Male	All	+1.405	<.001	8	view →
THCA	All	II,III,IV	−0.802	<.001	8	view →
KIRP	All	III,IV	−1.316	<.001	7	view →
BRCA	All	III,IV	−1.718	<.001	6	view →
UCEC	All	II,III,IV	−0.944	.009	4	view →
CHOL	Female	All	−4.936	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CYP39A1–KIRC

Open the KIRC breakdown →