CXorf58

Across TCGA cell cohorts, CXorf58 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CXorf58-associated genes across cancer lineages are IL36A, MT1B, and TSPAN16. Each is linked with CXorf58 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXorf58-to-partner and partner-to-CXorf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36A grouped by CXorf58-low versus CXorf58-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXorf58→partner) and Y-score (partner→CXorf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IL36A →	+0.085	+5.169	<.001	.005	3	1
BREAST	MT1B →	+0.113	+5.169	<.001	.005	3	1
OVARY	TSPAN16 →	+0.046	+3.841	<.001	.003	3	1
OVARY	WDR64 →	+0.065	+3.592	<.001	.006	3	1
OVARY	GPR148 →	+0.042	+3.095	<.001	.009	3	1
OVARY	MRGPRX2 →	+0.012	+3.405	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

IL36A by CXorf58 expression — BREAST

Explore this box plot interactively →