CXorf58

Across TCGA pan-cancer cohorts, CXorf58 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CXorf58’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CXorf58 RNA is repressed in tumor relative to normal tissue. In most cancer types CXorf58 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where CXorf58 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXorf58 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.348	<.001	12	view →
KIRP	Male	All	−0.324	<.001	9	view →
THCA	Male	All	−0.307	<.001	9	view →
KICH	Male	All	−0.569	<.001	8	view →
LIHC	All	All	+0.066	<.001	6	view →
HNSC	Male	III,IV	+0.096	.015	4	view →
CHOL	Male	All	+0.118	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CXorf58–KIRC

Open the KIRC breakdown →