CXorf58

Across TCGA pan-cancer cohorts, CXorf58 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CXorf58 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher CXorf58 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CXorf58 expression acts as an unfavorable survival marker, although some lineages such as SKCM and PAAD show a favorable association.

KICH, SKCM, and BLCA are the cancer types where CXorf58 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.695	1.000	.002	94	view →
SKCM	OS	Median	II,III,IV	0.411	0.227	<.001	73	view →
BLCA	OS	Quartile	II,III,IV	0.671	0.862	.001	33	view →
UVM	OS	Tertile	III,IV	0.456	0.915	.016	22	view →
PAAD	DFS	Quartile	All	0.538	0.160	.004	20	view →
LGG	DFS	Tertile	All	0.610	0.860	<.001	18	view →
CHOL	DFS	Tertile	All	0.665	0.183	.007	17	view →
MESO	DFS	Quartile	IV	0.186	0.580	.006	15	view →
LIHC	DFS	Median	All	0.490	0.587	.011	14	view →
ACC	OS	Median	All	0.931	0.817	.023	12	view →
LUSC	OS	Median	II,III,IV	0.893	0.646	.019	6	view →
KIRC	DFS	Median	IV	0.404	0.611	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CXorf58–KICH (OS)

Open the KICH breakdown →