CXorf56

Across TCGA patient cohorts, CXorf56 mutation is significantly associated with the RNA expression of many other genes, with 934 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXorf56-associated genes across cancer lineages are MBD3L3, SOX5-AS1, and MIR6798. Each is linked with CXorf56 in more than 2 cancer types. Because this analysis shows association rather than direction, both CXorf56-to-partner and partner-to-CXorf56 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by CXorf56-low versus CXorf56-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXorf56→partner) and Y-score (partner→CXorf56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MBD3L3 →	+0.078	+6.309	<.001	.001	3	3
COAD	SOX5-AS1 →	+0.369	+4.693	<.001	<.001	3	2
COAD	MIR6798 →	+0.424	+4.917	<.001	.003	3	2
SKCM	LONRF2P2 →	+0.079	+4.513	.001	.009	3	1
SKCM	RN7SL105P →	+0.195	+5.034	<.001	.002	3	1
SKCM	MTCO3P28 →	+0.132	+4.563	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 934 associations by consensus.

MBD3L3 by CXorf56 expression — LUSC

Explore this box plot interactively →